acute lymphoblastic leukemia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12943	SNDX-5613		Epigenetic Reader Domain , Histone Methyltransferase
	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.		Epigenetic Reader Domain , Histone Methyltransferase
T7955	EB-3D		Apoptosis , AMPK , AChR
	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.		Apoptosis , AMPK , AChR
T8308	NL-1		Mitochondrial Metabolism , Autophagy
	NL-1 is a mitoNEET inhibitor with antileukemic effect.		Mitochondrial Metabolism , Autophagy
TP1115	L-Asparaginase	L-ASNase	Others
	L-Asparaginase (L-ASNase) (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment.Asparaginase is an enzyme that is used as a medication. As a medication, L-a...		Others
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T74710	YX-2-107		CDK
	YX-2-107 is a selective and potent CDK6-degrading PROTAC with an IC50 value of 4.4 nM.YX-2-107 inhibits RB phosphorylation and FOXM1 expression in vitro, and inhibits the development of Ph+ ALL in rats.YX-2-107 can be us...		CDK
T1477	AICAR	NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)	Mitophagy , YAP , AMPK , Autophagy
	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.		Mitophagy , YAP , AMPK , Autophagy
T72984	(Rac)-SHIN2		Others
	(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL).		Others
T76790	Inotuzumab		Others
	Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4 antibody targeting CD22. Inotuzumab is a naked antibody to Inotuzumab ozogamicin and can be used to synthesize antibody-active molecule conjugator...		Others
T21302L	UNC 569 hydrochloride	UNC 569 hydrochloride (1350547-65-7 Free base)	TAM Receptor , TAM Receptor
	UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydr...		TAM Receptor , TAM Receptor
T36944	Ara-G		Nucleoside Antimetabolite/Analog
	Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...		Nucleoside Antimetabolite/Analog
T30688	Calaspargase pegol
	Calaspargase pegol is used to treat acute lymphoblastic leukemia.
T24189	J9	J-9,J 9
	J9 is an inhibitor of Glucocorticoid resistance. J9 reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia.
T20858	Metanilic acid	m-Anilinesulfonic acid,m-Sulfanilic acid
	Metanilic acid, an anti-cancer drug, is used to treat several malignancies including choriocarcinoma and pediatric acute lymphoblastic leukemia.
T31672	Erythrofuranosyladenine	9-β-D-Erythrofuranosyladenine,ETA
	Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute l...
T21301	Lesinurad sodium	Lesinurad,RDEA 594,RDEA-594,RDEA594
	UNC569, the first small-molecule MER inhibitor, inhibits Mer activation and downstream signaling through ERK1/2 and AKTwith. UNC569 shows efficacy against acute lymphoblastic leukemia in vitro and in vivo.
T36575	HDAC3 Inhibitor
	HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In add...
T4310L2	Prexasertib mesylate	LY-2606368,LY2606368,LY 2606368
	Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a...
T39799	S2157	S2157
	S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri...